Precision measurements of heavy-flavor hadroproduction at the Large Hadron Collider (LHC) have the ability to probe heavy-flavor parton distribution functions (PDFs) in the proton. Sensitivity of inclusive meson production cross section measurements at LHCb 13 TeV to the bottom-quark PDF is illustrated by using theory predictions obtained with a the S-ACOT-MPS general mass variable flavor number (GMVFN) scheme within the QCD factorization formula. This approach can easily be extended to other heavy-flavor production processes, such as boson production in association with a bottom- or a charm-jet. The inclusion of such measurements will represent an important improvement for future global QCD analyses that aim at reducing uncertainties of heavy-flavor PDFs, provided that a consistent general mass treatment in collisions is used. This work is related to the activities of the Snowmass topic groups EF03, and EF06.